Ruthenium catalyzed β-C(sp3)–H functionalization on the ‘privileged’ piperazine nucleus

• DOI: 10.1039/c7cc05604d
• Publication Date: 2017-08-30T15:33:20Z
• Authors: V. Murugesh; Christian Bruneau; Mathieu Achard; Apurba Ranjan Sahoo; Gangavaram V. M. ...; Surisetti Suresh
• Keywords: Surface Modification; Piperazine

β-C(sp3)-H functionalization on the 'privileged' piperazine nucleus has been disclosed using ruthenium catalysis. The catalyzed synthesis of a variety fused indoles from ortho-piperazinyl (hetero)aryl aldehydes is presented. This transformation takes place via dehydrogenation followed by an intramolecular nucleophilic addition transient enamine moiety onto carbonyl group and aromatization cascade.