A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP1-1)

• DOI: 10.1039/c7cc05829b
• Publication Date: 2017-08-21T14:03:23Z
• Authors: Yuko Shishido; Fumiaki Tomoike; Yasuaki Kimura; Keiko Kuwata; Takato Yano; Kenji Fukui; Haruka Fujikawa; Yoshitaka Sekido; Yuko Murakami-Tonami; Tomoshi Kameda; Satoshi Shuto; Hiroshi Abe
• Keywords: 0301 basic medicine; Structure-Activity Relationship; 0303 health sciences; 03 medical and health sciences; Dose-Response Relationship, Drug; Glutathione S-Transferase pi; Molecular Structure; Humans; Enzyme Inhibitors; Molecular Dynamics Simulation; 01 natural sciences; 0104 chemical sciences; 3. Good health

We herein report the first covalent G-site-binding inhibitor for GST, GS-ESF (1), which irreversibly inhibited the GSTP1-1 function.