Synthesis of imidazole-activated ribonucleotides using cyanogen chloride

• DOI: 10.1039/c7cc08489g
• Publication Date: 2017-12-21T09:03:48Z
• Authors: Ruiqin Yi; Yayoi Hongo; Albert C. Fahrenbach
• Keywords: Imidazole; Cyanogen bromide

We report the syntheses of ribonucleoside 5'-monophosphates activated with imidazole, using a mechanism which relies on in situ generation cyanogen chloride from reaction cyanide anion hypochlorous acid. Cyanogen reacts rapidly imidazole to form diimidazole imine as major product, species affords activation their 5'-phosphorimidazolides.