Palladium-catalyzed enantioselective C(sp2)–H arylation of ferrocenyl ketones enabled by a chiral transient directing group

• DOI: 10.1039/c7cc09273c
• Publication Date: 2017-12-21T14:58:00Z
• Authors: Jiancong Xu; Yang Liu; Jinling Zhang; Xiaohua Xu; Zhong Jin
• Keywords: Transient (computer programming)

Palladium-catalyzed enantioselective C(sp2)-H activation of ferrocenyl ketones is achieved through utilizing catalytic, inexpensive l-tert-leucine as a chiral transient directing group. The transformation allows rapid access to ferrocene scaffolds simultaneously possessing planar- and stereogenic central chirality, widely applied in the ferrocene-based ligand families.