Early maternal separation induces preference for sucrose and aspartame associated with increased blood glucose and hyperactivity

• DOI: 10.1039/c7fo00408g
• Publication Date: 2017-07-03T04:33:47Z
• Authors: L. Aya-Ramos; C. Contreras-Vargas; J. L. Rico; Z. Dueñas
• Keywords: Aspartame; Separation (statistics); Blood sugar

Early life stress and exposure to sweeteners lead physiological behavioral alterations in adulthood. Nevertheless, many genetic environmental factors as well the neurobiological mechanisms that contribute development of these disorders are not fully understood. Similarly, evidence about long-term metabolic effects early is limited inconsistent. This study used an animal model maternal separation during breastfeeding (MS) analyze on consumption sweeteners, weight gain, blood glucose locomotion. Rats were housed under a reversed light/dark cycle (lights off at 7:00 h) with ad libitum access water food. In MS protocol, pups separated from dam for 6 h per day two periods 180 minutes (7:00-10:00 13:00-16:00 dark phase postnatal (PND) 1 PND 21. Non-separated (NS) served controls. On 22 rats grouped by sex treatment. From 26 50 sucrose aspartame provided rats, sweetener intake, body glucose-related measures scored. 50, both male female exposed open field test obtain locomotion anxiety-related measures. Results showed intake adolescence resulted increased hyperactivity but rats. Data suggest combination could be risk factor chronic diseases such diabetes, alterations.