Phytol stimulates the browning of white adipocytes through the activation of AMP-activated protein kinase (AMPK) α in mice fed high-fat diet

• DOI: 10.1039/c7fo01817g
• Publication Date: 2018-03-05T04:03:52Z
• Authors: Fenglin Zhang; Wei Ai; Xiaoquan Hu; Yingying Meng; Cong Yuan; Han Su; Lina Wang; Xiaotong Zhu; Ping Gao; Gang Shu; Qingyan Jiang; Songbo Wang
• Keywords: Male; 0301 basic medicine; 2. Zero hunger; Adipogenesis; Gene Expression Regulation, Developmental; AMP-Activated Protein Kinases; Diet, High-Fat; Lipid Metabolism; Enzyme Activation; Mice, Inbred C57BL; Mice; Random Allocation; 03 medical and health sciences; Phytol; 3T3-L1 Cells; Dietary Supplements; Animals; Adipocytes, Beige; Anti-Obesity Agents; Obesity; Protein Kinase Inhibitors; Biomarkers; Adiposity

In vivo and in vitro studies show that phytol stimulates the browning of mice iWAT and formation of brown-like adipocytes in the differentiated 3T3-L1 through the activation of the AMPKα signaling pathway.