A novel 3-D bio-microfluidic system mimicking in vivo heterogeneous tumour microstructures reveals complex tumour–stroma interactions

• DOI: 10.1039/c7lc00191f
• Publication Date: 2017-07-10T17:33:51Z
• Authors: Qihui Fan; Ruchuan Liu; Yang Jiao; Chunxiu Tian; James D. Farrell; Wenwen Diao; Xiaochen Wang; Fengrong Zhang; Wei Yuan; Haibo Han; Jinfeng Chen; Yue Yang; Xixiang Zhang; Fangfu Ye; Ming Li; Zhongcan Ouyang; Liyu Liu
• Keywords: 0303 health sciences; 03 medical and health sciences; Cell Line, Tumor; Cell Culture Techniques; Tumor Microenvironment; Humans; Equipment Design; Microfluidic Analytical Techniques; Models, Biological; Extracellular Matrix; Fluorescent Dyes; 3. Good health

A 3-D microfluidic system consisting of microchamber arrays embedded in a collagen hydrogel with tunable biochemical gradients was constructed for investigating interactions between invasive breast cancer cells and stromal cells.