Simultaneous electrical recording of cardiac electrophysiology and contraction on chip

• DOI: 10.1039/c7lc00210f
• Publication Date: 2017-04-18T16:53:27Z
• Authors: Fang Qian; Chao Huang; Yi-Dong Lin; Anna N. Ivanovskaya; Thomas J. O'Hara; Ross H. Booth; Cameron J. Creek; Heather A. Enright; David A. Soscia; Anna M. Belle; Ronglih Liao; Felice C. Lightstone; Kristen S. Kulp; Elizabeth K. Wheeler
• Keywords: 0301 basic medicine; 03 medical and health sciences; Lab-On-A-Chip Devices; Induced Pluripotent Stem Cells; Cell Culture Techniques; Models, Cardiovascular; Action Potentials; Humans; Myocytes, Cardiac; Cardiac Electrophysiology; Microelectrodes; Cells, Cultured

We report a new heart-on-chip design capable of electrical stimulation, recording of growth, contraction and activating map from in vitro-cultured human cardiac tissues.