An EGFRvIII targeted dual-modal gold nanoprobe for imaging-guided brain tumor surgery

• DOI: 10.1039/c7nr01077j
• Publication Date: 2017-05-17T11:53:39Z
• Authors: Qi Yue; Xihui Gao; Yang Yu; Yang Li; Wei Hua; Kun Fan; Ren Zhang; Jun Qian; Liang Chen; Cong Li; Ying Mao
• Keywords: Nanoprobe; Brain tumor

Surgery is a mainstay to treat malignant brain tumors. However, due the infiltrative nature of these tumors, it great challenge for surgeons accurately identify and excise all tumor foci. EGFRvIII, variant epidermal growth factor receptor (EGFR), found in 20% glioblastoma cases, which with highest malignancy. In this study, we developed an EGFRvIII-targeted nanoprobe guide surgery by pre-operatively defining boundary via magnetic resonance imaging (MRI) intra-operatively guiding resection surface-enhanced Raman scattering (SERRS) imaging. vivo MRI studies show that delineates orthotopic EGFRvIII+ U87MG xenograft higher target background ratio than control without targeting specificity. With assistance handheld scanner, successfully guided tracking its characteristic SERRS signal peaks. Ex microscopy histological images verified precisely demarcated no residual neoplastic foci were observed bed. This dual-modal not only resection, but also overcame shift induced false-positive real-timely co-registering pre-operative intra-operative images. promising improvement diagnostic accuracy surgical outcome glioblastoma.