Highly regio- and stereoselective trans-iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides

• DOI: 10.1039/c7ob01470h
• Publication Date: 2017-08-09T11:33:26Z
• Authors: Yang Xi; Guohao Zhu; Luning Tang; Shihan Ma; Dongming Zhang; Rong Zhang; Guangke He; Hongjun Zhu
• Keywords: Halogenation; Stereoisomerism; Chemistry Techniques, Synthetic; Amides; 01 natural sciences; Catalysis; Iodine; 0104 chemical sciences

A highly regio- and stereoselective <italic>trans</italic>-iodofluorination of <italic>N</italic>-(1-alkynyl)amides with NIS Et₃N·3HF was achieved, affording (<italic>E</italic>)-α-fluoro-β-iodoenamides in moderate to excellent yields.