Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA

• DOI: 10.1039/c7ob02113e
• Publication Date: 2017-09-26T16:33:06Z
• Authors: Karoline Gangesta...; Jørn Eivind Tungen; Patricia Regina S...; Romain Alexandre ...; Jesmond Dalli; Trond Vidar Hansen; Anders Vik
• Keywords: 0301 basic medicine; Unsaturated; 0303 health sciences; Molecular Structure; Neutrophils; Fatty Acids; Anti-Inflammatory Agents; Stereoisomerism; 540; 01 natural sciences; Leukotriene B4; 0104 chemical sciences; 3. Good health; 03 medical and health sciences; Fatty Acids, Unsaturated; Arachidonate 15-Lipoxygenase; Epoxy Compounds; Humans

Biomolecular investigations using synthetic ePDn-3 DPAhave been performed to study its role in the biosynthesis of the specialized pro-resolving mediator PD1n-3 DPA.