Structural insight into inhibition of REV7 protein interaction revealed by docking, molecular dynamics and MM/PBSA studies

• DOI: 10.1039/c7ra03716c
• Publication Date: 2017-05-24T12:53:57Z
• Authors: Xiaodong Ren; Rui Zeng; Changwei Wang; Mingming Zhang; Chengyuan Liang; Zhonghai Tang; Jinfeng Ren
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences

The inhibitors of the REV7/REV3L protein interaction bind to the two pockets of REV7 divided by the ‘safety-belt’ structure, as revealed by computational modeling.