Site-selective bromination of sp3 C–H bonds

• DOI: 10.1039/c7sc04611a
• Publication Date: 2017-11-20T10:32:52Z
• Authors: Shyam Sathyamoorthi; Shibdas Banerjee; J. Du Bois; Noah Z. Burns; Richard N. Zare
• Keywords: Chemistry; 01 natural sciences; 0104 chemical sciences

A method for converting sp3 C–H to C–Br bonds using an N-methyl sulfamate directing group is described. For all sulfamates examined, bromination occurs with high selectivity at the γ-carbon, affording a predictable method for C–H bond halogenation.