Immunomodulatory vasoactive intestinal peptide amphiphile micelles

• DOI: 10.1039/c8bm00466h
• Publication Date: 2018-05-15T07:34:30Z
• Authors: Rui Zhang; Caitlin N. Leeper; Xiaofei Wang; Tommi A. White; Bret D. Ulery
• Keywords: Chemokine CCL22; Lipopolysaccharides; 0301 basic medicine; Tumor Necrosis Factor-alpha; Macrophages; Anti-Inflammatory Agents; Gene Expression; Dendritic Cells; T-Lymphocytes, Regulatory; Protein Structure, Secondary; 3. Good health; Mice; Surface-Active Agents; 03 medical and health sciences; Animals; Humans; Immunologic Factors; B7-2 Antigen; Cells, Cultured; Micelles; Vasoactive Intestinal Peptide

Two different vasoactive intestinal peptide (VIP) amphiphiles have been formulated which readily form micelles of varying shapes. Interestingly, VIP micelle structure has been found to directly correlate to anti-inflammatory behavior providing evidence that these biomaterials can serve as a promising new therapeutic modality.