Enhanced local cancer therapy using a CA4P and CDDP co-loaded polypeptide gel depot

• DOI: 10.1039/c8bm01442f
• Publication Date: 2019-01-24T05:48:14Z
• Authors: Shuangjiang Yu; Shu Wei; Liang Liu; Desheng Qi; Jiayu Wang; Guojun Chen; Wanying He; Chaoliang He; Xuesi Chen; Zhen Gu
• Keywords: Depot; Cancer Therapy

Cancer combination therapy based on drug co-delivery systems provides an effective strategy for enhancing treatment efficacy and reducing side effects. In this work, a new through of combretastatin A4 disodium phosphate (CA4P) cisplatin (CDDP) was developed the local colon cancer, in situ thermo-gelling hydrogel (mPEG-b-PELG). The results indicated that material possessed concentration-dependent thermogelling properties tunable vivo biodegradability. Also, loaded gel could regulate vitro release behaviors both CDDP CA4P, which promoted vessel disrupting effects CA4P compared with free after 48 h. Although co-loaded induced less cell death co-treated group, depot showed highest antitumor other experimental groups peritumoral injection toward C26 tumor bearing mice.