Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments

• DOI: 10.1039/c8cc01355a
• Publication Date: 2018-04-11T02:14:46Z
• Authors: Yann Fichou; Michael Vigers; Andrew K. Goring; Neil A. Eschmann; Songi Han
• Keywords: Amyloid; 0303 health sciences; Pyrrolidines; Molecular Structure; Heparin; Thiosulfonic Acids; Membrane Proteins; Protein Aggregation, Pathological; Peptide Fragments; 3. Good health; 03 medical and health sciences; Alzheimer Disease; Humans; Spin Labels; Amino Acid Sequence; Protein Multimerization; Protein Structure, Quaternary; Protein Binding

Tau filaments formed with heparin are structurally different from Alzheimer's disease extracted human brains. Heparin creates heterogeneous in which tau proteins locally stretched and have minimal large-domain structuration.