Electrodrugs: an electrochemical prodrug activation strategy

• DOI: 10.1039/c8cc04151b
• Publication Date: 2018-07-25T01:37:41Z
• Authors: Daniel J. Norman; Eva González-Fern...; Jessica Clavadets...; Lulu Tucker; Matteo Staderini; Andrew R. Mount; Alan F. Murray; Mark Bradley
• Keywords: 0303 health sciences; 03 medical and health sciences; Organoplatinum Compounds; Coordination Complexes; Humans; Antineoplastic Agents; Apoptosis; Prodrugs; Electrochemical Techniques; HCT116 Cells; Electrodes; Oxidation-Reduction

Controlled activation of a Pt(<sc>iv</sc>) prodrug into its active Pt(<sc>ii</sc>) form within cellular context, using an electrochemical strategy.