Diversity-oriented synthesis of imidazo[2,1-a]isoquinolines

• DOI: 10.1039/c8cc05390a
• Publication Date: 2018-07-19T10:35:30Z
• Authors: Shaoyu Mai; Yixin Luo; Xianyun Huang; Zhenghao Shu; Bingnan Li; Yu Lan; Qiuling Song
• Keywords: Annulation

Herein, we report an efficient and practical strategy for the synthesis of five types imidazo[2,1-<italic>a</italic>]isoquinolines <italic>via</italic> Cp*Rh^III-catalyzed [4+2] annulation 2-arylimidazoles α-diazoketoesters, whose structural substituted diversity at 5- or 6-position can be precisely controlled by α-diazoketoester coupling partners.