Rational design of new cyclic analogues of the antimicrobial lipopeptide tridecaptin A1

• DOI: 10.1039/c8cc05790g
• Publication Date: 2018-09-04T13:54:54Z
• Authors: Ross D. Ballantine; Yong-Xin Li; Pei-Yuan Qian; Stephen A. Cochrane
• Keywords: Lipopeptide; Rational design; Cyclic peptide

Non-ribosomal peptides (NRPs) are a rich source of antibiotic candidates. However, it was recently discovered that resistance to NRPs can be mediated by d-stereoselective peptidases. The tridecaptins, class selectively target Gram-negative bacteria, degraded the d-peptidase TriF. Through analysis solution NMR structure tridecaptin A1, we have rationally synthesized new cyclic analogues retain strong antimicrobial activity and resistant