Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs

• DOI: 10.1039/c8cc06284f
• Publication Date: 2018-11-19T14:54:24Z
• Authors: Nils Hellwig; Oliver Peetz; Zainab Ahdash; Igor Tascón; Paula J. Booth; Vedrana Mikusevic; Marina Diskowski; Argyris Politis; Yvonne Hellmich; Inga Hänelt; Eamonn Reading; Nina Morgner
• Keywords: Models, Molecular; 0301 basic medicine; 570; 0303 health sciences; Lipid Bilayers; Maleates; Membrane Proteins; 16. Peace & justice; Lipids; Mass Spectrometry; Chemistry; 03 medical and health sciences; POLYMERS; Particle Size; Styrene; LIPIDS

Other than more widely used methods, the use of styrene maleic acid copolymers allows the direct extraction of membrane proteins from the lipid bilayer into SMALPs keeping it in its native lipid surrounding.