A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury

• DOI: 10.1039/c8cc07304j
• Publication Date: 2018-11-20T12:05:00Z
• Authors: Jingli Hou; Haiyan He; Saipeng Huang; Meng Qian; Jie Wang; Xiaoli Tan; Guifang Han; Yuguang Song; Zhelong Xu; Yangping Liu
• Keywords: Superoxide radical

A novel mitochondria-targeted superoxide-responsive nitric oxide donor was developed by incorporation of diphenylphosphinyl and triphenylphosphonium groups into diazeniumdiolate, enabling remarkable protection against ischemia/reperfusion injury in H9c2 cells isolated rat hearts.