Use of an NIR-light-responsive CO nanodonor to improve the EPR effect in photothermal cancer treatment

• DOI: 10.1039/c8cc07873d
• Publication Date: 2018-11-02T04:04:24Z
• Authors: Chongchong Wang; Yanqing Li; Xianqing Shi; Jiahong Zhou; Lin Zhou; Shaohua Wei
• Keywords: Photothermal effect; Cancer Treatment

The carbon monoxide (CO)-carrying palladium nanosheet (PdNS-CO) was exploited as a photothermally triggered donor of CO. Irradiating material containing PdNS-CO with 808 nm-wavelength light caused rapid heating the material, triggering release enhanced permeability and retention (EPR) effect found to be improved by such released CO resulted in an increase accumulation at tumors hence promoted its use photothermal therapy (PTT) using low laser power density.