Transition metal substituted sandwich-type polyoxometalates with a strong metal–C (imidazole) bond as anticancer agents

• DOI: 10.1039/c8cc07884j
• Publication Date: 2018-12-21T01:04:23Z
• Authors: Hongxia Zhao; Li Tao; Fengmin Zhang; Ying Zhang; Yanqing Liu; Hongjie Xu; Guowang Diao; Lubin Ni
• Keywords: Imidazole; Polyoxometalate

The metal–carbon bond plays a pivotal role in the structural stabilities and biological activities of metal-based anticancer drugs. strong M–C_imi is first introduced into sandwich-type POMs [Na_0.7M_5.3(H₂O)₂(imi)₂(Himi)(SbW₉O₃₃)₂]⁶⁻, (M = Ni^II (<bold>1</bold>), Co^II (<bold>2</bold>), imi imidazole).