Transition metal substituted sandwich-type polyoxometalates with a strong metal–C (imidazole) bond as anticancer agents
Molecular Structure
Imidazoles
0211 other engineering and technologies
Antineoplastic Agents
Apoptosis
02 engineering and technology
01 natural sciences
3. Good health
0104 chemical sciences
HEK293 Cells
Cell Line, Tumor
Metals, Heavy
S Phase Cell Cycle Checkpoints
Organometallic Compounds
Transition Elements
Humans
DOI:
10.1039/c8cc07884j
Publication Date:
2018-12-21T01:04:23Z
AUTHORS (8)
ABSTRACT
The metal–carbon bond plays a pivotal role in the structural stabilities and biological activities of metal-based anticancer drugs. The strong M–Cimi bond is first introduced into sandwich-type POMs [Na0.7M5.3(H2O)2(imi)2(Himi)(SbW9O33)2]6−, (M = NiII (1), CoII (2), imi = imidazole).
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