Transition metal substituted sandwich-type polyoxometalates with a strong metal–C (imidazole) bond as anticancer agents

• DOI: 10.1039/c8cc07884j
• Publication Date: 2018-12-21T01:04:23Z
• Authors: Hongxia Zhao; Li Tao; Fengmin Zhang; Ying Zhang; Yanqing Liu; Hongjie Xu; Guowang Diao; Lubin Ni
• Keywords: Molecular Structure; Imidazoles; 0211 other engineering and technologies; Antineoplastic Agents; Apoptosis; 02 engineering and technology; 01 natural sciences; 3. Good health; 0104 chemical sciences; HEK293 Cells; Cell Line, Tumor; Metals, Heavy; S Phase Cell Cycle Checkpoints; Organometallic Compounds; Transition Elements; Humans

The metal–carbon bond plays a pivotal role in the structural stabilities and biological activities of metal-based anticancer drugs. The strong M–Cimi bond is first introduced into sandwich-type POMs [Na0.7M5.3(H2O)2(imi)2(Himi)(SbW9O33)2]6−, (M = NiII (1), CoII (2), imi = imidazole).