Transition metal substituted sandwich-type polyoxometalates with a strong metal–C (imidazole) bond as anticancer agents

Molecular Structure Imidazoles 0211 other engineering and technologies Antineoplastic Agents Apoptosis 02 engineering and technology 01 natural sciences 3. Good health 0104 chemical sciences HEK293 Cells Cell Line, Tumor Metals, Heavy S Phase Cell Cycle Checkpoints Organometallic Compounds Transition Elements Humans
DOI: 10.1039/c8cc07884j Publication Date: 2018-12-21T01:04:23Z
ABSTRACT
The metal–carbon bond plays a pivotal role in the structural stabilities and biological activities of metal-based anticancer drugs. The strong M–Cimi bond is first introduced into sandwich-type POMs [Na0.7M5.3(H2O)2(imi)2(Himi)(SbW9O33)2]6−, (M = NiII (1), CoII (2), imi = imidazole).
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