Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines

• DOI: 10.1039/c8cc08769e
• Publication Date: 2019-01-04T15:04:35Z
• Authors: Natalia Curado; Guillaume Dewaele...; Sophie Poty; Jason S. Lewis; Maria Contel
• Keywords: 0301 basic medicine; Magnetic Resonance Spectroscopy; Cell Survival; Receptor, ErbB-2; Breast Neoplasms; Trastuzumab; 3. Good health; 03 medical and health sciences; Antineoplastic Agents, Immunological; Cell Line, Tumor; MCF-7 Cells; Humans; Female; Gold

Trojan horse based design affords antibody gold conjugates containing linkers that display HER2-mediated toxicity in breast cancer cell lines.