PROTAC-mediated crosstalk between E3 ligases

• DOI: 10.1039/c8cc09541h
• Publication Date: 2019-01-16T12:05:10Z
• Authors: Christian Steinebach; Hannes Kehm; Stefanie Lindner; Lan Phuong Vu; Simon Köpff; Álvaro López Mármol; Corinna Weiler; Karl G. Wagner; Michaela Reichenz...; Jan Krönke; Michael Gütschow
• Keywords: 0303 health sciences; Cell Survival; Ubiquitin-Protein Ligases; Ligands; Thalidomide; Small Molecule Libraries; 03 medical and health sciences; Von Hippel-Lindau Tumor Suppressor Protein; Cell Line, Tumor; Proteolysis; Humans; Dimerization; Adaptor Proteins, Signal Transducing; Peptide Hydrolases

Small-molecule heterobifunctional degraders can effectively control protein levels and are useful research tools.