Small-molecule-based human genome G4 profiling reveals potential gene regulation activity

• DOI: 10.1039/c8cc10052g
• Publication Date: 2019-01-24T11:40:51Z
• Authors: Weiwu Zeng; Fan Wu; Chaoxing Liu; Yan Yang; Bingyao Wang; Yushu Yuan; Jiaqi Wang; Yuqi Chen; Boshi Fu; Zhiguo Wu; Xiang Zhou
• Keywords: DNA Replication; G-Quadruplexes; Small Molecule Libraries; 0301 basic medicine; 03 medical and health sciences; Base Sequence; Gene Expression Regulation; Genome, Human; Molecular Probes; Biotin; Humans; Polyethylene Glycols

Small-molecule-based G4 isolation from genomic DNA has enabled the identification of a total of 51 446 PQSs (potential G-quadruplex sites).