Synthesis, structure, docking and cytotoxic studies of ferrocene–hormone conjugates for hormone-dependent breast cancer application

• DOI: 10.1039/c8dt01856a
• Publication Date: 2018-11-22T18:04:12Z
• Authors: José A. Carmona-N...; Alberto Santana; Arnold L. Rheingold; Enrique Meléndez
• Keywords: 0303 health sciences; Molecular Structure; Cell Survival; Metallocenes; Estrogen Receptor alpha; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Estrogens; 3. Good health; Molecular Docking Simulation; Structure-Activity Relationship; 03 medical and health sciences; Cell Line, Tumor; Drug Design; Humans; Female; Ferrous Compounds; Amino Acids; Protein Binding

Ferrocene–estrogen conjugates can be recognized by ERα, suggesting that estrogens could serve as vectors to target specifically breast cancer cell lines.