Luteolin inhibits proliferation and induces apoptosis of human melanoma cells in vivo and in vitro by suppressing MMP-2 and MMP-9 through the PI3K/AKT pathway

• DOI: 10.1039/c8fo02013b
• Publication Date: 2019-01-09T05:04:20Z
• Authors: Xin Yao; Wei Jiang; Danhong Yu; Zhaowei Yan
• Keywords: 0301 basic medicine; Dose-Response Relationship, Drug; Mice, Nude; Apoptosis; Neoplasms, Experimental; 3. Good health; Mice; Phosphatidylinositol 3-Kinases; 03 medical and health sciences; Gene Expression Regulation; Matrix Metalloproteinase 9; Cell Movement; Cell Line, Tumor; Animals; Humans; Matrix Metalloproteinase 2; Luteolin; Melanoma; Proto-Oncogene Proteins c-akt; Cell Proliferation

Since the incidence rate of malignant melanoma is increasing annually, development drugs against cell metastasis has become more urgent.