Eco-friendly decarboxylative cyclization in water: practical access to the anti-malarial 4-quinolones

• DOI: 10.1039/c8gc03570a
• Publication Date: 2019-01-09T07:04:16Z
• Authors: Yue Ma; Yongping Zhu; Dong Zhang; Yuqing Meng; Tian Tang; Kun Wang; Ji Ma; Jigang Wang; Peng Sun
• Keywords: 01 natural sciences; 6. Clean water; 0104 chemical sciences; 3. Good health

An eco-friendly decaboxylative cyclization in water has been developed to construct 4-quinolones from readily available isatoic anhydrides and 1,3-dicarbonyl compounds.