Synthesis and antitumor mechanisms of two novel platinum(ii) complexes with 3-(2′-benzimidazolyl)-7-methoxycoumarin

• DOI: 10.1039/c8mt00125a
• Publication Date: 2018-07-26T15:37:58Z
• Authors: Qi-Pin Qin; Shu-Long Wang; Ming-Xiong Tan; Zhen-Feng Wang; Xiao-Ling Huang; Qing-Min Wei; Bei-Bei Shi; Bi-Qun Zou; Hong Liang
• Keywords: Models, Molecular; Ovarian Neoplasms; Molecular Structure; Organoplatinum Compounds; Cell Cycle; Antineoplastic Agents; Apoptosis; Ligands; 01 natural sciences; Mitochondria; 0104 chemical sciences; 3. Good health; Proto-Oncogene Proteins c-myc; Coumarins; Drug Resistance, Neoplasm; Tumor Cells, Cultured; Humans; Female; Enzyme Inhibitors; Promoter Regions, Genetic; Telomerase; Cell Proliferation

<bold>Pt2</bold> is a novel telomerase inhibitor binding to c-myc promoter elements, which arrests the cell cycle at G2/M phase and induces apoptosis causes mitochondrial dysfunction.