The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease

• DOI: 10.1039/c8nr00632f
• Publication Date: 2018-04-26T12:34:57Z
• Authors: Farhang Aliakbari; Hossein Mohammad-...; Nasrollah Rezaei-...; Stefan Becker; Faezeh Dehghani E...; Hadieh Alsadat Es...; Hassan Bardania; Amir Tayaranian M...; Joanna F. Colling...; Gunna Christiansen; Markus Zweckstetter; Daniel E. Otzen; Dina Morshedi
• Keywords: therapy [Parkinson Disease]; 1,2-Dipalmitoylphosphatidylcholine; 610; PC12 Cells; Polyethylene Glycols; chemistry [1,2-Dipalmitoylphosphatidylcholine]; 03 medical and health sciences; drug effects [Neurons]; Animals; Humans; metabolism [Calcium]; metabolism [Reactive Oxygen Species]; Neurons; 0303 health sciences; chemistry [Liposomes]; Parkinson Disease; Rats; Physical sciences; chemistry [Polyethylene Glycols]; Cholesterol; Chemical sciences; chemistry [alpha-Synuclein]; Liposomes; alpha-Synuclein; Nanoparticles; Calcium; Reactive Oxygen Species; ddc:600; chemistry [Cholesterol]; chemistry [Nanoparticles]

The mechanism of zwitterionic nanoliposomes to reduce α-synuclein aggregation and neurotoxicity.