pH and reduction-activated polymeric prodrug nanoparticles based on a 6-thioguanine-dialdehyde sodium alginate conjugate for enhanced intracellular drug release in leukemia

• DOI: 10.1039/c8py00577j
• Publication Date: 2018-05-11T11:04:21Z
• Authors: Yanming Wan; Ying Bu; Jiaming Liu; Jia Yang; Weiquan Cai; Yihua Yin; Wenjin Xu; Peihu Xu; Jingli Zhang; Meng He
• Keywords: 02 engineering and technology; 0210 nano-technology; 3. Good health

Synthesis schematics of DSA and 6-TG-DSA as well as processes of PPN self-assembly and its pH/GSH dual stimuli-response release of the conjugated 6-TG.