Rh(iii)-Catalyzed directed C–H carbenoid coupling reveals aromatic bisphosphonates inhibiting metallo- and Serine-β-lactamases

• DOI: 10.1039/c8qo00009c
• Publication Date: 2018-02-01T07:33:50Z
• Authors: Chen Zhang; Yan-chi Pu; Zhu-Jun Yu; Cheng-yong Wu; Jürgen Brem; Michael A. McDonough; Christopher J. Sc...; Guo-Bo Li; Yong Wu
• Keywords: Diphosphonates; Carbenoid; Methylene

The C–H coupling of arenes with diazo-methylene-diphosphonates enables efficient synthesis new diphosphonates, which exhibit dual MBL and SBL inhibition.