Searching for original natural products by molecular networking: detection, isolation and total synthesis of chloroaustralasines

• DOI: 10.1039/c8qo00429c
• Publication Date: 2018-06-07T06:04:22Z
• Authors: F. Olivon; C. Apel; P. Retailleau; P. M. Allard; J. L. Wolfender; D. Touboul; F. Roussi; M. Litaudon; S. Desrat
• Keywords: Isolation

Four unprecedented chlorinated monoterpenyl quinolones have been isolated using a molecular networking based prioritisation strategy. The bio-inspired total synthesis of chloroaustralasine A involving chloroperoxydase-mediated hydroxychlorination is described.