Effects of pore size on in vitro and in vivo anticancer efficacies of mesoporous silica nanoparticles

• DOI: 10.1039/c8ra03914c
• Publication Date: 2018-07-10T09:04:31Z
• Authors: Jie Li; Suqin Shen; Fei Kong; Ting Jiang; Cui Tang; Chunhua Yin
• Keywords: Chemistry; 02 engineering and technology; 0210 nano-technology; 01 natural sciences; 0104 chemical sciences; 3. Good health

Mesoporous silica nanoparticles (MSN) have been widely applied for drug delivery systems. To investigate the effects of pore size on anticancer efficacies, MSN with different sizes but similar particle and surface charges were synthesized via a microemulsion method. The structures characterized by transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), N2 adsorption-desorption isotherms. Doxorubicin loaded (DOX/MSN) prepared minimum loading capacity was detected in DOX/MSN 2.3 nm (DOX/MSN2). 8.2 (DOX/MSN8) showed comparable amount comparison ones 5.4 (DOX/MSN5). In vitro release profiles that DOX/MSN5 could DOX quickly completely. Compared DOX/MSN2 DOX/MSN8, higher cellular uptake nucleic concentration QGY-7703 cells, which led to efficient cell-apoptosis induction anti-proliferation effect, thus optimal vivo activities. Taken together, these results highlighted importance would serve as guideline rational design cancer therapy.