Oligosaccharide synthesis on soluble high-molecular weight pHEMA using a photo-cleavable linker

• DOI: 10.1039/c8ra08252a
• Publication Date: 2018-12-12T08:33:59Z
• Authors: Abhishek Vartak; Sandeep Thanna; Kyle Meyer; Miranda Dermanelian; Steven J. Sucheck
• Keywords: Oligosaccharide; Linker; Trisaccharide

Oligosaccharide synthesis on organic solvent soluble, high molecular weight poly(2-hydroxyethylmethylacrylate) (pHEMA) is described. The pHEMA-bound oligosaccharide could be recovered after each reaction in 90-95% yield using a precipitation method. methodology was used to synthesize model tri-galactoside 48% overall and trisaccharide from the outer core domain of Pseudomonas aeruginosa lipopolysacchride (LPS) 39% yield. use photo-cleavable linker also demonstrated produce reducing-end protected oligosaccharides.