Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer

• DOI: 10.1039/c9bm00323a
• Publication Date: 2019-06-28T13:04:01Z
• Authors: Yi-An Cheng; I-Ju Chen; Yu-Cheng Su; Kai-Wen Cheng; Yun-Chi Lu; Wen-Wei Lin; Yuan-Chin Hsieh; Chien-Han Kao; Fang-Ming Chen; Steve R. Roffler; Tian-Lu Cheng
• Keywords: Internalization; Bispecific antibody; Anticancer drug; Efficacy

One-step formulation of BsAb with PLD is a simple method to enhance tumor specificity, internalization and the anti-cancer activity.