GSH/pH dual-responsive biodegradable camptothecin polymeric prodrugs combined with doxorubicin for synergistic anticancer efficiency

• DOI: 10.1039/c9bm00425d
• Publication Date: 2019-05-29T04:04:14Z
• Authors: Jun Li; Zu-E. Hu; Xian-Ling Yang; Wan-Xia Wu; Xiu Xing; Bo Gu; Yan-Hong Liu; Na Wang; Xiao-Qi Yu
• Keywords: Drug Carriers; Polymers; Antineoplastic Agents; Hep G2 Cells; Hydrogen-Ion Concentration; Glutathione; 01 natural sciences; Permeability; 0104 chemical sciences; 3. Good health; Drug Liberation; Doxorubicin; Humans; Camptothecin; Prodrugs; Micelles; Cell Proliferation

GSH and pH dual-responsive camptothecin polymeric prodrugs combined doxorubicin for synergistic drug delivery to highly improved selectivity and synergy benefiting from good long-term stability, better internalization and sensitive dual-responsibility.