Light-enhanced sponge-like carbon nanozyme used for synergetic antibacterial therapy

• DOI: 10.1039/c9bm00705a
• Publication Date: 2019-07-10T13:35:32Z
• Authors: Juqun Xi; Gen Wei; Qiuwen Wu; Zhilong Xu; Yingwei Liu; Jie Han; Lei Fan; Lizeng Gao
• Keywords: Sponge; Carbon fibers

Bacterial infection and the issue of antibiotic resistance have become one major public health problems worldwide. Thus, searching for new antibacterial agents is urgently required. Hydrogen peroxide, H2O2, as a traditional bactericide, applied widely medical treatments. However, relatively high concentration H2O2 used in clinical setting usually inhibits wound healing even damages normal tissues during disinfection. Here, we synthesized N-doped sponge-like carbon spheres (N-SCSs), which showed excellent mimicking activities multiple enzymes, including peroxidase, oxidase, superoxide dismutase, catalase. We then utilized peroxidase-like activity N-SCSs to convert low-concentration into radical oxygen species resist bacteria. The data that performance against Gram-negative bacteria (Escherichia coli), Gram-positive (Staphylococcus aureus), multidrug-resistant was improved through catalytic reaction N-SCSs. Importantly, besides generating heat bacteria, near-infrared laser exposure also promoted peroxidase N-SCSs, further generate kill In addition, this catalytic-photothermal strategy demonstrated accelerated recovery infected wounds an animal model. our work provides synergetic anti-infection strategy, expands application carbon-based nanozymes biomedicine.