Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide

• DOI: 10.1039/c9bm01644a
• Publication Date: 2019-12-26T09:23:33Z
• Authors: Federica Sodano; Robert J. Cavanagh; Amanda K. Pearce; Loretta Lazzarato; Barbara Rolando; Aurore Fraix; Thais F. Abelha; Catherine E. Vasey; Cameron Alexander; Vincenzo Taresco; Salvatore Sortino
• Keywords: Antibiotics, Antineoplastic; Dose-Response Relationship, Drug; Polymers; 02 engineering and technology; Nitric Oxide; Photochemical Processes; Cell Line; 3. Good health; Structure-Activity Relationship; Doxorubicin; Humans; Nanoparticles; Nitric Oxide Donors; Drug Screening Assays, Antitumor; 0210 nano-technology; Cell Proliferation

Combination of Doxorubicin with light-regulated NO release achieved through formulation strategy of tailored polymeric conjugate nanoparticles may open new treatment modalities to improve cancer therapies.