Crosslinking catalytic hairpin assembly for high-contrast imaging of multiple mRNAs in living cells

• DOI: 10.1039/c9cc01033e
• Publication Date: 2019-03-07T03:04:42Z
• Authors: Du-Juan Huang; Ting Cao; Zhi-Mei Huang; Zhenkun Wu; Li-Juan Tang; Jian-Hui Jiang
• Keywords: 0301 basic medicine; Cell Survival; Optical Imaging; Biosensing Techniques; DNA; 01 natural sciences; Catalysis; Nanostructures; 0104 chemical sciences; 03 medical and health sciences; Cross-Linking Reagents; Cell Line, Tumor; Humans; RNA, Messenger

A novel DNA nanotetrad mediated crosslinking catalytic hairpin assembly (CCHA) is reported to generate clumps of cross-linked mesh products for high-contrast and simultaneous imaging multiple mRNAs in living cells.