Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors

• DOI: 10.1039/c9cc04872c
• Publication Date: 2019-12-02T17:30:05Z
• Authors: Yasuaki Kimura; Zhaoma Shu; Mika Ito; Naoko Abe; Kosuke Nakamoto; Fumiaki Tomoike; Satoshi Shuto; Yoshihiro Ito; Hiroshi Abe
• Keywords: 0303 health sciences; 03 medical and health sciences; Ultraviolet Rays; RNA Precursors; RNA Interference; RNA, Circular; RNA, Small Interfering; Apolipoproteins B

We herein report a new approach for RNA interference, so-called “build-up RNAi” approach, where single-strand circular RNAs with a photocleavable unit or disulfide moiety were used as siRNA precursors.