Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging

• DOI: 10.1039/c9cc05657b
• Publication Date: 2019-09-16T06:43:32Z
• Authors: Limiao Shi; Christophe Nguyen; Morgane Daurat; Abdelhamid Chiheb...; Wajda Smirani; Mireille Blanchar...; Magali Gary-Bobo; Olivier Mongin; Christine Paul-Roth; Frédéric Paul
• Keywords: Fluorenes; Cell Membrane Permeability; Photosensitizing Agents; Porphyrins; Molecular Structure; Singlet Oxygen; Cell Survival; Infrared Rays; Optical Imaging; Biocompatible Materials; [CHIM.THER]Chemical Sciences/Medicinal Chemistry; 01 natural sciences; Polyethylene Glycols; 0104 chemical sciences; Structure-Activity Relationship; Microscopy, Fluorescence, Multiphoton; Photochemotherapy; MCF-7 Cells; [CHIM]Chemical Sciences; Humans

Three new biocompatible porphyrin-based oxygen photosensitisers were tested in vitro on breast cancer cells via 2P-PDT: one of them, 66 times more active than H2TPP, gave quite promising results for theranostic applications.