Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization

• DOI: 10.1039/c9cc05703j
• Publication Date: 2019-09-03T15:14:05Z
• Authors: Gülçin Ekineker; Christophe Nguyen; Sümeyra Bayır; Sofia Dominguez Gil; Ümit İşci; Morgane Daurat; Anastasia Godefroy; Laurence Raehm; Clarence Charnay; Erwan Oliviero; Vefa Ahsen; Magali Gary-Bobo; Jean-Olivier Durand; Fabienne Dumoulin
• Keywords: Internalization; Mesoporous organosilica

Mesoporous organosilica nanoparticles (PHT-PMO) have been prepared from an octa-triethoxysilylated Zn phthalocyanine precursor. These PHT-PMO had no dark toxicity but high phototoxicity when irradiated at 650 nm, and remarkable near-infrared excited 760 810 nm. The were then aminated to promote electrostatic complexation with siRNA. Transfection experiments performed upon NIR irradiation photochemical internalization was very efficient, leading 65% luciferase extinction in MCF-7 cancer cells expressing stable luciferase.