An automated modular assembly line for drugs in a miniaturized plant

• DOI: 10.1039/c9cc06945c
• Publication Date: 2019-12-09T15:24:19Z
• Authors: Chuntian Hu; Christopher J. Testa; Wei Wu; Khrystyna Shvedova; Dongying Erin Shen; Ridade Sayin; Bhakti S. Halkude; Federica Casati; Paul Hermant; Anjana Ramnath; Stephen C. Born; Bayan Takizawa; Thomas F. O’Connor; Xiaochuan Yang; Sukumar Ramanujam; Salvatore Mascia
• Keywords: Assembly line; Line (geometry)

We report here a fully automated, end-to-end, integrated continuous manufacturing process for small-molecule generic medication with built-in quality assurance. The entire fits into box of 30.7 m2 modular footprint and total residence time less than 30 h, throughput up to 40.3 × 106 tablets per year.