Elastase-triggered H2S delivery from polymer hydrogels

• DOI: 10.1039/c9cc08752d
• Publication Date: 2020-01-02T10:23:35Z
• Authors: Mingjun Zhou; Yun Qian; Yumeng Zhu; John Matson
• Keywords: 0301 basic medicine; Hydrogels; Protective Agents; Cell Line; Polyethylene Glycols; Rats; Oxidative Stress; 03 medical and health sciences; Doxorubicin; Carboxymethylcellulose Sodium; Oximes; Animals; Humans; Hydrogen Sulfide; Leukocyte Elastase

A polymer hydrogel was prepared that underwent a gel-to-sol transition in response to the enzyme elastase, triggering release of H2S from incorporated S-aroylthiooximes.