Organometallic ciprofloxacin conjugates with dual action: synthesis, characterization, and antimicrobial and cytotoxicity studies

• DOI: 10.1039/c9dt03948a
• Publication Date: 2019-12-10T10:46:15Z
• Authors: Łukasz Szczupak; Aleksandra Kowalczyk; Damian Trzybiński; Krzysztof Woźniak; Gracia Mendoza; Manuel Arruebo; Dietmar Steverding; Paweł Stączek; Konrad Kowalski
• Keywords: Dose-Response Relationship, Drug; Molecular Structure; Cell Survival; 500; Antineoplastic Agents; Microbial Sensitivity Tests; 540; Gram-Positive Bacteria; 01 natural sciences; Anti-Bacterial Agents; Cell Line; 0104 chemical sciences; Mice; Structure-Activity Relationship; Ciprofloxacin; Gram-Negative Bacteria; Organometallic Compounds; Animals; Humans; Drug Screening Assays, Antitumor; Cell Proliferation; HeLa Cells

Organometallic ciprofloxacin conjugates were synthesized and two mechanisms of antimicrobial activity were demonstrated. The first mechanism involves the inhibition of type IIA topoisomerases and the second involves ROS generation in bacterial cells.