Mangiferin improves hepatic damage-associated molecular patterns, lipid metabolic disorder and mitochondrial dysfunction in alcohol hepatitis rats

• DOI: 10.1039/c9fo00153k
• Publication Date: 2019-05-10T02:04:23Z
• Authors: Mengran Li; Chunxiao Wu; Hongbin Guo; Ce Chu; Mingye Hu; Chengyan Zhou
• Keywords: Mangiferin; Metabolic disorder

This study was conducted to investigate the beneficial effects and possible mechanism of action mangiferin (MF) in alcohol hepatitis (AH) rats. Building on our previous study, damage-associated molecular patterns (DAMPs), lipid metabolic disorder mitochondrial dysfunction were investigated. MF effectively regulated abnormal liver function, levels alcohol, FFAs metal elements serum. More importantly, improved expression mRNA protein PPAR-γ, OPA-1, Cav-1, EB1, NF-κB p65, NLRP3, Cas-1 IL-1β, decreased positive rates HSP90, HMGB1, SYK, CCL20, C-CAS-3, C-PARP STARD1. Additionally, fumarate, cAMP, xanthurenic acid d-glucurone-6,3-lactone, increased hippuric phenylacetylglycine, then adjusted changes phenylalanine metabolism, TCA cycle ascorbate aldarate pathways. The above results suggested that can prevent AH by modulating specific AH-associated genes, potential biomarkers pathways rats, etc.