Isoleucine attenuates infection induced byE. colichallenge through the modulation of intestinal endogenous antimicrobial peptide expression and the inhibition of the increase in plasma endotoxin and IL-6 in weaned pigs

• DOI: 10.1039/c9fo00218a
• Publication Date: 2019-05-16T11:07:31Z
• Authors: Man Ren; Shuang Cai; Tong Zhou; Shihai Zhang; Shenghe Li; Erhui Jin; Chuanyan Che; Xiangfang Zeng; Tao Zhang; Shiyan Qiao
• Keywords: Isoleucine

Enteric infection is a major cause of morbidity and mortality in both humans animals worldwide. Immunotherapy against intestinal well-known alternative to the antibiotic strategy. Herein, we demonstrated that isoleucine significantly suppressed multiplication E. coli presence IPEC-J2 cells. Isoleucine supplementation enhanced concentrations total plasma protein IgA pigs compared alanine control diet, while inhibiting increase endotoxin IL-6 contents induced by challenge. A significant interaction between challenge diet treatment was found red blood cell volume. improved expression porcine β-defensin-1 (pBD-1), pBD-2, pBD-3, pBD-114 pBD-129 jejunum ileum with or without Conclusively, attenuated caused possibly through increasing β-defensin weaned pigs.