Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria

• DOI: 10.1039/c9md00031c
• Publication Date: 2019-03-12T09:34:28Z
• Authors: Ross D. Ballantine; Conor E. McCallion; Elie Nassour; Sima Tokajian; Stephen A. Cochrane
• Keywords: Gram-Negative Bacteria; Gram

Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, family linear lipo-tridecapeptides, easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as d/l diaminobutyric acid d-allo-isoleucine, significantly increasing cost synthesis. Herein, we report series new tridecaptin derivatives that much cheaper to synthesize retain multidrug-resistant